No Silver Bullet in GMO Golden Rice

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NO SILVER BULLET IN GMO GOLDEN RICE

Blog > No Silver Bullet in GMO Golden Rice

No Silver Bullet in GMO Golden Rice

Published
October 12, 2023
Category
Blog, GMO

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If you are a GMO debate follower, you probably belong to one of four corners in this boxing ring. (Why do rings have corners, you may wonder, but that is a debate for a different time)

Anti-GMO
You may believe humans should not tamper with evolution or you are deeply concerned with unforeseen environmental effects that GMOs may trigger. You are dubious about corporate intent to do good or you may have a religious opposition to tampering with God’s creatures. Irrespective of the reasons, you probably oppose genetic research even if it is deeply regulated. You will vote “Yes” on GMO labeling where you would demand companies declare GMO ingredients in food labels. Ideally though, you may support a complete ban on GMO in foods.

Pro GMO & anti-labeling
You support genetic research and believe responsible and competent scientists are the ones controlling the process. You think the good it can do far outweighs the risks. You may believe the market must be allowed to prevail in this debate and not the regulators and that the environmentalists are habitually shrill and overstating risks. Consequently you think there is no need to legislate GMO labeling and consumers are not going to be better served by this bureaucracy.

Pro GMO, but Pro-labeling
You perhaps believe genetic modification is almost evolutionary or that the GMO train has inexorably left the platform and there is no turning back. You might even support GMO in cash crops (Cotton, Tobacco etc.) provided there are substantial experimental controls on consequences. You may believe the standards for testing must be raised and include not just efficacy, clinical and safety trials but also a new level of environmental trials. You do not easily support genetic modification in food crops and hence will absolutely support GMO labeling in all food be it in retail packs or in food service establishments.

GMO Fence sitter
Perhaps you are relatively new to the debate or have been overexposed but unconvinced by arguments on both sides. Perhaps your family is divided on the issue and you are the impartial referee, or equally likely you just don’t know enough and are smart enough not to make up your mind with half-truths. You may be pro- science & left-of-center or you are pro-environment but right of center. In this debate the fence appears to you the least prickly place for now.

Irrespective of your preferred corner in this debate, you are probably familiar with Golden Rice and have probably read a bit about it. It has become the poster child for the GMO lobby and viewed as a Trojan horse for the watchdogs. Let me explain.

Partially developed by the International Rice Research Institute (IRRI) in Manila, Philippines Golden Rice is a genetically modified crop that has a gene from corn and (animal) bacterium embedded in a rice variety that helps produce beta carotene which is a precursor to Vitamin A in the human body. This is being paraded as a major breakthrough. Why? WHO claims, quarter to half a million children goes blind annually & half of them perish within a year of losing their sight due to Vitamin A deficiency. Now, you can see where this argument is headed. IRRI chief Mr. Robert Ziegler and the GMO lobby are full of righteous indignation that environmentalists and Governments should even oppose such a miracle as Golden Rice instead of rushing to restore the sights of millions of children around the world. No surprise, opponents of GMO are feeling a bit flat-footed. How do you oppose something like this without being labeled a child killer?! It appears the corporate “evil” shoe is now on the other foot. Let’s look at some facts on Golden Rice before we raise our voices from our respective four corners.

It is now axiomatic that Vitamin A deficiency causes child blindness and that consuming Beta Carotene helps the body produce Vitamin A.
Golden Rice has been in development for more than 20 years and it does seem to have the extra beta-carotene that even lends it color to the grain making it golden instead of the characteristic white.
The original developers and scientists working on Golden Rice were powered by a sense of greater good and they even mandated that the grain when fully developed and distributed to famers be on a not-for-profit basis.
Field trials conducted across several countries did produce the beta- carotene but the affordability and yields are still not satisfactorily established.
Governments in Japan, China, India and even the Philippines (where the rice was developed) are yet to authorize this GMO crop.
The not-for-profit mandate seems to have gotten a bit blurred along the way since it now appears to be owned by Agro Chemical giant Syngenta, even as work on it continues at IRRI

It may appear Golden Rice is being touted for it potential more than for its performance and is clearly being defended even before its fully commercialized. Notwithstanding these hurdles, scientists will ultimately get it right and pressure on governments will only mount. But in this entire debate over the years, all of us have gotten so anchored in the GMO vs. non-GMO debate that the elephant in the room is no longer visible to us. Here is the big question that is not being asked. Can GMO Golden Rice really prevent child blindness? The unfortunate but practical answer is No. This was explained to me in a recent conversation I had recently with a pre-eminent doctor and national award winning eye specialist (who had not heard about Golden Rice!). He said that in his experience, he had seldom witnessed child blindness solely due to Vitamin A deficiency! Malnutrition and dehydration, he explained prevent Vitamin A absorption in the body and it is this lack of bioavailability of Vitamin A that triggers blindness. No amount of fortified rice will prevent blindness without first addressing the basic problems of nutrition and dehydration that plagues poor children in dozens of countries in Asia and Africa. This is akin to treating a symptom while ignoring the cause.
Countries will need to continue work towards improving food security and ensure their children get the basic macro nutrients in the form of carbohydrates, fats and proteins and then travel through Maslow’s hierarchy of micronutrients such as Vitamin A, Iron, Iodine etc.

Whichever corner of the ring you now find yourself in, the fight on Golden Rice deserves to be taken to a different theater, free from the clutter and the noise of the GMO debates.

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GMO Foods – A Note of Caution

GMO FOODS – A NOTE OF CAUTION

Blog > GMO Foods – A Note of Caution

GMO Foods – A Note of Caution

Published
October 12, 2023
Category
Blog, GMO

By Ashok Vasudevan If hybridization was the cornerstone of the Green revolution of the 60s & 70s, some would like to see GMOs (Genetically Modified Organisms) as the trigger for the next agricultural revolution. This paper will argue that it is far from it. It is true that humans have been tinkering with crops for thousands of years. Evidence of selective breeding can be found in Asia dating back to 7800 BCE. About the same time, in the Andes, the natives transformed a noxious plant into Potatoes, the 4^th most important crop for humans today. The top 3 (Rice, Wheat and Corn) all came from wild inedible grasses through massive human intervention through the ages. The same process of selective breeding also spawned seedless grapes and watermelons, the fat heads of broccoli and virtually every fruit & vegetable we consume. These are inspiring stories of evolution. So far so good. But a discontinuous change happened in 1992. Using a newly acquired DNA technology, the Flavr Savr Tomato became the first genetically engineered vegetable. An inhibitor added to its DNA made it firmer with a longer shelf life. With this, the floodgates opened for GMOs. Most will however argue the GMO tomato is not a flavr savr. In fact it’s the flavor thief.  But loss of flavor is only part of the larger problem with GMOs. In 1995 we saw corn, a staple ingredient in processed foods in the US, genetically engineered to produce their own pesticides by using genes from the B.thuringiensis bacteria. By 1996, we saw a host of herbicide resistant crop seeds, allowing for entire fields to be sprayed with weed killing chemicals without damaging the crops.  All of this being done under the FDA’s (GRAS) Generally Recognized as Safe standard, rather than the more stringent Federal Food, Drug, and Cosmetic Act (FFDCA) for food additive tolerance requirements. In the short 25 years since its creation, we have seen the proliferation of GMOs across the US farmland and in supermarkets.  Genetically modified seeds account for 81% of the corn and 94% of the soybeans grown in the US, while in a typical grocery store 70% of what Americans find on shelves are made from ingredients that have been genetically modified! The US is the largest consumer of GMOs in the world. So it may be instructive to draw some lessons from there before countries outline their own policy towards genetic modification of food.

A bunch of arguments are made to promote benefits of GMO seeds. Main among them are higher yields, resistance to certain herbicides, and improved nutrition.  For farmers looking for a way to increase their profitability, switching to GMOs seemed like a silver bullet.  But only a few short years into what was hailed as the “next revolution in food” the GMO movement is facing serious headwinds both from within the industry and from a larger consumer movement. A good place to start is an acknowledgement that Americans are the loudest critics of GMOs today.  They are no longer fringe protesters but the mainstream of society. The millennial pushback is a tsunami and major supermarkets and literally thousands of stores across the country are supporting the non-GMO label. In fact Wholefoods has stated that by 2018 ALL its products will be non-GMO. (Let’s take this more seriously- Amazon just bought Wholefoods!) Now lets turn to the three specific arguments in support of GMOs:   1. GMO crops increase yields- so farmers are enriched: FALSEAfter over 20 years of use, no scientific study conclusively supports GMO use as increasing crop yields. Europe, which has resisted the GMO movement, continues to match US corn and sugar beet yields using non-GMO seeds and less herbicides and pesticides!

The promise of Increased yields of GMO crops was a carrot to many farmers who struggled with the high costs of running a farm. Is their life better today? After 25 years of GMO existence the brutal fact is that apart from the colossal Federal farm subsidy of $25 Billion last year; over 20% of American farmers are on the national food assistance program (SNAP), earlier known as food stamps! 2. GMOs help reduce Agrochemical use in the farm (like Herbicides): FALSE In theory, planting herbicide resistant seeds allows for a heavy spraying of a weedkiller at the beginning of the season but less spraying during the course of the growing year, reducing overall consumption. Unfortunately, the theory only held for a few years following the introduction of GMOs.  The Rise of the Superweed: Chemical resistant Superweeds are starting to appear on GMO farms across the US. Resistant to one or more types of weedkillers, superweeds are forcing farmers to increase and vary the chemicals used in a single growing season or worse, reverting back to heavy tilling to remove weeds which erodes topsoil. The increased use of herbicides further raises concern of runoff water laden with toxins entering the water supply.

A picture above is worth a 1000 words. So much for reduced herbicides since the introduction of GMOs about 25 years ago.

When weeds become resistant to herbicides, new GMOs must be formulated to be resistant to additional toxic chemicals. More R&D costs equal higher seed prices. Farmers who habitually use GMO seeds become addicted to purchasing the newly reformulated seeds and their corresponding reformulated herbicides in a never ending vicious cycle. 3. GMOs make more Nutritious Food: FALSE The first attempt to increase the nutritional value of the food we consume by genetic modification was the Golden Rice project. Promoted as a way to prevent childhood blindness caused by a deficiency in Vitamin A, a gene from corn and (animal) bacterium was embedded in a rice variety that helps produce beta carotene, a precursor to Vitamin A in the human body. Field trials of the rice never never reached the affordability and yields required to make it commercially viable. In addition, the original premise that a Vitamin A deficiency alone caused blindness was flawed as it was later proven that a combination of dehydration and malnutrition in children prevented the absorption of Vitamin A causing the blindness. Golden Rice was fighting a symptom, not the cause. No comprehensive studies have been done to check the phytochemical dilution in vegetables as they get genetically modified. Without external fortification it is today virtually impossible to genetically create desirable phytochemicals, micronutrients and alkaloids within a vegetable and have them bio-available to humans. No, GMOs have not enhanced human nutrition. The Next Emerging non-tariff trade barrier- GMO Foods While the GMO/Non-GMO battle continues, health conscious consumers around the world are increasingly purchasing natural and organic foods. Acreage certified as organic is at an all-time high, and many of the high profile food producers are entering the organic market. (By definition, organic foods are certified non-GMO) American consumers are becoming more wary of what ingredients are in their food and are calling for mandatory GMO labeling by food manufacturers. While several food and agrochemical companies are fighting this, it seems almost inevitable that more descriptive labeling is on the way and with that, the debate will almost certainly escalate.Supermarkets are already demanding non GMO labels. Regulators are scrambling to keep pace. The foundation for a ban on GMO imports into the US and other developed markets (or at any rate increased trade barriers) is an all too realistic scenario. It appears that the next green wave of food production is at a crossroads in the US, but the manufacturers of GMOs are not waiting to see which direction the American consumer takes. They are aggressively marketing to European and Asian countries, using the same promises they made to American farmers. They question is – will history repeat.
The march of science is unstoppable and genetics is no exception. Science allows us to dream big. But the pursuit of a big dream demands careful calibration and the study of unintended consequences. Our future prosperity lies in our intelligent application of science and not in the mindless pursuit of what can be done as opposed to what ought to be done. It is true that dozens of countries (28 as of today) have allowed the growth of genetically modified crops in their farms. But it is sobering and heartening to know more countries have banned it than adopted it. Among them Russia, China and the European Union. India is on the fence but veering towards permitting GMOs. It will do well to pause. India has the potential to be the breadbasket to the world. Many things can go wrong in the pursuit of that vision. Adopting GMOs is certainly one of them Acknowledgement: Deep debt of gratitude to Bob Wells ( Program Coordinator at The MAV Foundation, www.mavfoundation.org) for researching and providing me the early draft for this piece.